NCK1 antibody
Product Specifications
Background
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Synonyms
SH2/SH3 adapter protein NCK1|Cytoplasmic protein NCK1|NCK adapter protein 1 (Nck-1)|SH2/SH3 adapter protein NCK-alpha|NCK1|NCK
Gene ID
4690
UniProt
P16333
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NCK adaptor protein 1
Target
NCK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, FC, IP
Field of Research
Immunology, Cardiovascular, Developmental biology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
43 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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