CDH2 antibody
Product Specifications
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) .
Synonyms
Cadherin-2|CDw325|Neural cadherin (N-cadherin) |CDH2|CDHN|NCAD
Gene ID
1000
UniProt
P19022
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Cadherin 2, type 1, N-cadherin (neuronal)
Target
CDH2
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, IHC, WB
Field of Research
Signal Transduction, Cardiovascular, Immunology, Neuroscience, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:10000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
1G1
Tested Applications
ELISA, IHC, WB
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