MRAP2 antibody
Product Specifications
Background
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity) . May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R) ; however, additional evidences are required in vivo.
Synonyms
Melanocortin-2 receptor accessory protein 2 (MC2R accessory protein 2) |MRAP2|C6orf117
Gene ID
112609
UniProt
Q96G30
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Melanocortin 2 receptor accessory protein 2
Target
MRAP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Neuroscience, Signal Transduction, Immunology
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC
Curated Selection
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