MITF antibody
Product Specifications
Background
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) . Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) . Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Synonyms
Microphthalmia-associated transcription factor|Class E basic helix-loop-helix protein 32 (bHLHe32) |MITF|BHLHE32
Gene ID
4286
UniProt
O75030
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Microphthalmia-associated transcription factor
Target
MITF
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, FC, IP
Field of Research
Epigenetics, Metabolism, Immunology, Developmental biology, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, FC, IP
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