MICAL2 antibody
Product Specifications
Background
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Synonyms
[F-actin]-monooxygenase MICAL2|MICAL C-terminal-like protein (Mical-cL) |Molecule interacting with CasL protein 2 (MICAL-2) |MICAL2|KIAA0750|MICAL2PV1|MICAL2PV2|MICALCL
Gene ID
9645
UniProt
O94851
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Microtubule associated monoxygenase, calponin and LIM domain containing 2
Target
MICAL2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
95, 112 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF
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