MICAL1 antibody
Product Specifications
Background
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable) . Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.
Synonyms
[F-actin]-monooxygenase MICAL1|Molecule interacting with CasL protein 1 (MICAL-1) |NEDD9-interacting protein with calponin homology and LIM domains|MICAL1|MICAL|NICAL
Gene ID
64780
UniProt
Q8TDZ2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Microtubule associated monoxygenase, calponin and LIM domain containing 1
Target
MICAL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, FC
Field of Research
Signal Transduction, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, FC
Curated Selection
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