OGA antibody
Product Specifications
Background
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc(in vitro)(PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity(PubMed:24088714).
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc(in vitro), but has about six times lower specific activity than isoform 1.
CAS Number
9007-83-4
Synonyms
Protein O-GlcNAcase (OGA)|Beta-N-acetylglucosaminidase|Beta-N-acetylhexosaminidase|Beta-hexosaminidase|Meningioma-expressed antigen 5|N-acetyl-beta-D-glucosaminidase|N-acetyl-beta-glucosaminidase|Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT)|OGA|HEXC|KIAA0679|MEA5|MGEA5
Gene ID
10724
UniProt
O60502
Host
Mouse
Reactivity
Human
Immunogen
meningioma expressed antigen 5(hyaluronidase)
Target
OGA
Clonality
Monoclonal
Isotype
IgG2a
Clone
9B9
Applications
ELISA, WB, IF, IHC
Field of Research
Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
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