MED12 antibody

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

Mediator of RNA polymerase II transcription subunit 12|Activator-recruited cofactor 240 kDa component (ARC240)|CAG repeat protein 45|Mediator complex subunit 12|OPA-containing protein|Thyroid hormone receptor-associated protein complex 230 kDa component (Trap230)|Trinucleotide repeat-containing gene 11 protein|MED12|ARC240|CAGH45|HOPA|KIAA0192|TNRC11|TRAP230