MDM2 antibody
Product Specifications
Background
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Synonyms
E3 ubiquitin-protein ligase Mdm2|Double minute 2 protein (Hdm2)|Oncoprotein Mdm2|RING-type E3 ubiquitin transferase Mdm2|p53-binding protein Mdm2|MDM2
Gene ID
4193
UniProt
Q00987
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mdm2 p53 binding protein homolog (Mouse )
Target
MDM2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Epigenetics, Metabolism, Immunology, Cancer, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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