MDM2 antibody

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

E3 ubiquitin-protein ligase Mdm2|Double minute 2 protein (Hdm2) |Oncoprotein Mdm2|RING-type E3 ubiquitin transferase Mdm2|p53-binding protein Mdm2|MDM2