MARCKSL1 antibody
Product Specifications
Background
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems(By similarity).
Synonyms
MARCKS-related protein|MARCKS-like protein 1|Macrophage myristoylated alanine-rich C kinase substrate (Mac-MARCKS, MacMARCKS)|MARCKSL1|MLP|MRP
Gene ID
65108
UniProt
P49006
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
MARCKS-like 1
Target
MARCKSL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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