MAGEA3 antibody
Product Specifications
Background
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Synonyms
Melanoma-associated antigen 3|Antigen MZ2-D|Cancer/testis antigen 1.3 (CT1.3) |MAGE-3 antigen|MAGEA3|MAGE3
Gene ID
4102
UniProt
P43357
Host
Mouse
Reactivity
Human
Immunogen
Melanoma antigen family A, 3
Target
MAGEA3
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IHC
Field of Research
Cancer, Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35-55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
4E9
Tested Applications
ELISA, WB, IHC
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