LONP1 antibody
Product Specifications
Background
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory(StAR) protein.
Synonyms
Lon protease homolog, mitochondrial|LONHs|Lon protease-like protein (LONP)|Mitochondrial ATP-dependent protease Lon|Serine protease 15|LONP1|PRSS15
Gene ID
9361
UniProt
P36776
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
lon peptidase 1, mitochondrial
Target
LONP1
Clonality
Monoclonal
Isotype
IgG2a
Clone
9H10
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:10000; IHC: 1:400-1:1600; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
