KLHL22 antibody
Product Specifications
Background
Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint(SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
Synonyms
Kelch-like protein 22|KLHL22
Gene ID
84861
UniProt
Q53GT1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
kelch-like 22(Drosophila)
Target
KLHL22
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
72 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2046689-01 0.1 mL
APC-Linked Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1)
Ask
View Details MBS2046689-02 0.2 mL
APC-Linked Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1)
Ask
View Details MBS2046689-03 0.5 mL
APC-Linked Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1)
Ask
View Details 
MBS2046689-04 1 mL
APC-Linked Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1)
Ask
View Details MBS2046689-05 5 mL
APC-Linked Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1)
Ask
View Details