KIF7 antibody
Product Specifications
Background
Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms (PubMed:21633164) . Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity) . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity) . Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity) .
Synonyms
Kinesin-like protein KIF7|KIF7
Gene ID
374654
UniProt
Q2M1P5
Host
Rabbit
Reactivity
Human
Immunogen
Kinesin family member 7
Target
KIF7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB
Field of Research
Cell Division and Proliferation, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB
Immunogen Sequence
662-782aa
Curated Selection
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