KCNN4 antibody
Product Specifications
Background
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990) . Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614) .
Synonyms
Intermediate conductance calcium-activated potassium channel protein 4 (SK4, SKCa 4, SKCa4) |IKCa1 (IK1) |KCa3.1|KCa4|Putative Gardos channel|KCNN4|IK1|IKCA1|KCA4|SK4
Gene ID
3783
UniProt
O15554
Host
Rabbit
Reactivity
Human
Immunogen
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Target
KCNN4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
292-427aa
Curated Selection
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