KCNAB2 antibody

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900) . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity) . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity) . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900) . Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900) . Modulates the functional properties of KCNA5 (By similarity) . Enhances KCNB2 channel activity (By similarity) . Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity) . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity) .