KANK2 antibody
Product Specifications
Background
Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway(PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus(PubMed:22371500). May be involved in promotion of cell proliferation(By similarity).
Synonyms
KN motif and ankyrin repeat domain-containing protein 2|Ankyrin repeat domain-containing protein 25|Matrix-remodeling-associated protein 3|SRC-1-interacting protein (SIP, SRC-interacting protein, SRC1-interacting protein)|KANK2|ANKRD25|KIAA1518|MXRA3|SIP
Gene ID
25959
UniProt
Q63ZY3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
KN motif and ankyrin repeat domains 2
Target
KANK2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
95 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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