BCA

BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) [1][2][3].

Product Specifications

CAS Number

[979-88-4]

Product Name Alternative

Disodium bicinchoninate

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Beta-secretase

Type

Biochemical Assay Reagents

Related Pathways

Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BCA.html

Concentration

10mM

Purity

99.99

Solubility

7.5% Sodium bicarbonate : ≥ 50 mg/mL|DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4

Molecular Formula

C20H10N2Na2O4

Molecular Weight

388.29

Precautions

H315, H319, H335

References & Citations

[1]Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25 (9) :2158-63.|[2]Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056.|[3]Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8 (10) :637.