BCA
Product Specifications
UNSPSC Description
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD)[1][2][3].
Target Antigen
Beta-secretase
Type
Biochemical Assay Reagents
Related Pathways
Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BCA.html
Solubility
7.5% Sodium bicarbonate : ≥ 50 mg/mL|DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
Molecular Weight
388.29
References & Citations
[1]Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25(9):2158-63.|[2]Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056.|[3]Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8(10):637.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15908/BCA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15908/BCA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
979-88-4
Available Sizes
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