IST1 antibody
Product Specifications
Background
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480) . During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712) . Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888) .
Synonyms
IST1 homolog (hIST1) |Charged multivesicular body protein 8 (CHMP8) |Putative MAPK-activating protein PM28|IST1|KIAA0174
Gene ID
9798
UniProt
P53990
Host
Rabbit
Reactivity
Human
Immunogen
KIAA0174
Target
IST1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC, IP
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC, IP
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