IRF8 antibody
Product Specifications
Background
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS) ) . Plays a negative regulatory role in cells of the immune system. Involved in CD8 (+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity) .
Synonyms
Interferon regulatory factor 8 (IRF-8) |Interferon consensus sequence-binding protein (H-ICSBP, ICSBP) |IRF8|ICSBP1
Gene ID
3394
UniProt
Q02556
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Interferon regulatory factor 8
Target
IRF8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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