IL6 antibody
Product Specifications
Background
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 Plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
Synonyms
Interleukin-6 (IL-6) |B-cell stimulatory factor 2 (BSF-2) |CTL differentiation factor (CDF) |Hybridoma growth factor|Interferon beta-2 (IFN-beta-2) |IL6|IFNB2
Gene ID
3569
UniProt
P05231
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Interleukin 6 (interferon, beta 2)
Target
IL6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
Peptide
Curated Selection
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