IL6 antibody
Product Specifications
Background
Interleukin-6(IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 Plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
Synonyms
Interleukin-6 (IL-6)|B-cell stimulatory factor 2 (BSF-2)|CTL differentiation factor (CDF)|Hybridoma growth factor|Interferon beta-2 (IFN-beta-2)|IL6|IFNB2
Gene ID
3569
UniProt
P05231
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
interleukin 6(interferon, beta 2)
Target
IL6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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