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IL6 antibody

Product Specifications

Background

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 Plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Synonyms

Interleukin-6 (IL-6) |B-cell stimulatory factor 2 (BSF-2) |CTL differentiation factor (CDF) |Hybridoma growth factor|Interferon beta-2 (IFN-beta-2) |IL6|IFNB2

Gene ID

3569

UniProt

P05231

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Interleukin 6 (interferon, beta 2)

Target

IL6

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC, IF

Field of Research

Neuroscience, Immunology, Cardiovascular, Signal Transduction

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

24 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC, IF

Immunogen Sequence

Peptide

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