IL1R2 antibody
Product Specifications
Background
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Synonyms
Interleukin-1 receptor type 2 (IL-1R-2, IL-1RT-2, IL-1RT2) |CD121 antigen-like family member B|CDw121b|IL-1 type II receptor|Interleukin-1 receptor beta (IL-1R-beta) |Interleukin-1 receptor type II|Interleukin-1 receptor type 2, membrane form (mIL-1R2, mIL-1RII) |Interleukin-1 receptor type 2, soluble form (sIL-1R2, sIL-1RII) |IL1R2|IL1RB
Gene ID
7850
UniProt
P27930
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Interleukin 1 receptor, type II
Target
IL1R2
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IF
Field of Research
Immunology, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
7G9
Tested Applications
ELISA, WB, IF
Immunogen Sequence
14-343aa
Curated Selection
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