IL10RB antibody
Product Specifications
Background
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes(ISG), which contribute to the antiviral state.
Synonyms
Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta, IL-10R subunit beta, IL-10RB)|Cytokine receptor class-II member 4|Cytokine receptor family 2 member 4 (CRF2-4)|Interleukin-10 receptor subunit 2 (IL-10R subunit 2, IL-10R2)|IL10RB|CRFB4|D21S58|D21S66
Gene ID
3588
UniProt
Q08334
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
interleukin 10 receptor, beta
Target
IL10RB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
42-45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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