NFKBIA antibody
Product Specifications
Background
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Synonyms
NF-kappa-B inhibitor alpha|I-kappa-B-alpha (IkB-alpha, IkappaBalpha)|Major histocompatibility complex enhancer-binding protein MAD3|NFKBIA|IKBA|MAD3|NFKBI
Gene ID
4792
UniProt
P25963
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Target
NFKBIA
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
39 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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