NFKBIA antibody

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

NF-kappa-B inhibitor alpha|I-kappa-B-alpha (IkB-alpha, IkappaBalpha)|Major histocompatibility complex enhancer-binding protein MAD3|NFKBIA|IKBA|MAD3|NFKBI