IFIT3 antibody
Product Specifications
Background
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Synonyms
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3)|CIG49|ISG-60|Interferon-induced 60 kDa protein (IFI-60K)|Interferon-induced protein with tetratricopeptide repeats 4 (IFIT-4)|Retinoic acid-induced gene G protein (P60, RIG-G)|IFIT3|CIG-49|IFI60|IFIT4|ISG60
Gene ID
3437
UniProt
O14879
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
interferon-induced protein with tetratricopeptide repeats 3
Target
IFIT3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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