IDO1 antibody
Product Specifications
Background
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174) . Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885) . Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885) . Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885) . Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885) . Protects the fetus from maternal immune rejection (PubMed:25691885) .
Synonyms
Indoleamine 2,3-dioxygenase 1 (IDO-1) |Indoleamine-pyrrole 2,3-dioxygenase|IDO1|IDO|INDO
Gene ID
3620
UniProt
P14902
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Indoleamine 2,3-dioxygenase 1
Target
IDO1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:4000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
42 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
1-403aa, full length
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