IDH1 antibody
Product Specifications
Background
IDH1, also named as PICD and IDP, belongs to the isocitrate and isopropylmalate dehydrogenases family. It is a common feature of a major subset of primary human brain cancers. It can form a homodimer (PMID:15173171) .IDH1 mutation is always heterozygotic and IDH1 functions as a dimer, theoretically there will be 25% each wild type and mutant homo-dimers and 50% hetero-dimers present in the tumor cells (PMID:21079649) .
Synonyms
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH, IDH1) |Cytosolic NADP-isocitrate dehydrogenase|IDPc|NADP (+) -specific ICDH|Oxalosuccinate decarboxylase|IDH1|PICD
Gene ID
3417
UniProt
O75874
Host
Mouse
Reactivity
Human
Immunogen
Isocitrate dehydrogenase 1 (NADP+), soluble
Target
IDH1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
1G10
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
120-414aa
Curated Selection
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