IDH1 antibody
Product Specifications
Background
IDH1, also named as PICD and IDP, belongs to the isocitrate and isopropylmalate dehydrogenases family. It is a common feature of a major subset of primary human brain cancers. It can form a homodimer(PMID:15173171).IDH1 mutation is always heterozygotic and IDH1 functions as a dimer, theoretically there will be 25% each wild type and mutant homo-dimers and 50% hetero-dimers present in the tumor cells(PMID:21079649 ).
Synonyms
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH, IDH1)|Cytosolic NADP-isocitrate dehydrogenase|IDPc|NADP(+)-specific ICDH|Oxalosuccinate decarboxylase|IDH1|PICD
Gene ID
3417
UniProt
O75874
Host
Mouse
Reactivity
Human
Immunogen
isocitrate dehydrogenase 1(NADP+), soluble
Target
IDH1
Clonality
Monoclonal
Isotype
IgG1
Clone
1G10
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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