HSP90AA1 antibody
Product Specifications
Background
HSP90, encoded by HSP90AA1, is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.
Synonyms
Heat shock protein HSP 90-alpha|Heat shock 86 kDa (HSP 86, HSP86) |Lipopolysaccharide-associated protein 2 (LAP-2, LPS-associated protein 2) |Renal carcinoma antigen NY-REN-38|HSP90AA1|HSP90A|HSPC1|HSPCA
Gene ID
3320
UniProt
P07900
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Heat shock protein 90kDa alpha (cytosolic), class A member 1
Target
HSP90AA1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, FC
Field of Research
Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:8000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
4G10
Tested Applications
ELISA, WB, IHC, FC
Immunogen Sequence
380-732aa
Curated Selection
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