HSD3B7 antibody
Product Specifications
Background
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis(PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol(7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
CAS Number
9007-83-4
Synonyms
3 beta-hydroxysteroid dehydrogenase type 7|3 beta-hydroxysteroid dehydrogenase type VII (3-beta-HSD VII)|3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase (C(27) 3-beta-HSD)|Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase|HSD3B7
Gene ID
80270
UniProt
Q9H2F3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 7
Target
HSD3B7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
36 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
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