HNRNPC antibody
Product Specifications
Background
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621) . Specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm (6) A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671) . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621) .
Synonyms
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) |HNRNPC|HNRPC
Gene ID
3183
UniProt
P07910
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Heterogeneous nuclear ribonucleoprotein C (C1/C2)
Target
HNRNPC
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, FC
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, FC
Curated Selection
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