GZMB antibody
Product Specifications
Background
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Synonyms
Granzyme B|C11|CTLA-1|Cathepsin G-like 1 (CTSGL1) |Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease) |Fragmentin-2|Granzyme-2|Human lymphocyte protein (HLP) |SECT|T-cell serine protease 1-3E|GZMB|CGL1|CSPB|CTLA1|GRB
Gene ID
3002
UniProt
P10144
Host
Rabbit
Reactivity
Human
Immunogen
Granzyme B
Target
GZMB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
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