GSPT2 antibody
Product Specifications
Background
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome-and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Synonyms
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b, eRF3b) |G1 to S phase transition protein 2 homolog|GSPT2|ERF3B
Gene ID
23708
UniProt
Q8IYD1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
G1 to S phase transition 2
Target
GSPT2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
69 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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