GM2A antibody
Product Specifications
Background
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity) . Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
Synonyms
Ganglioside GM2 activator|Cerebroside sulfate activator protein|GM2-AP|Sphingolipid activator protein 3 (SAP-3) |Ganglioside GM2 activator isoform short|GM2A
Gene ID
2760
UniProt
P17900
Host
Mouse
Reactivity
Human
Immunogen
GM2 ganglioside activator
Target
GM2A
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
22 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9C9
Tested Applications
ELISA, WB
Immunogen Sequence
1-193aa
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