GLRB antibody
Product Specifications
Background
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine(PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1(PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability(PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents(PubMed:25445488).
Synonyms
Glycine receptor subunit beta|Glycine receptor 58 kDa subunit|GLRB
Gene ID
2743
UniProt
P48167
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
glycine receptor, beta
Target
GLRB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
56 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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