GLRA1 antibody
Product Specifications
Background
Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860) . Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272) . Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272) . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753) . Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) . Channel activity is potentiated by ethanol (PubMed:25973519) . Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity) .
Synonyms
Glycine receptor subunit alpha-1|Glycine receptor 48 kDa subunit|Glycine receptor strychnine-binding subunit|GLRA1
Gene ID
2741
UniProt
P23415
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Glycine receptor, alpha 1
Target
GLRA1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Curated Selection
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