GLRA1 antibody

Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860) . Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272) . Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272) . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753) . Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) . Channel activity is potentiated by ethanol (PubMed:25973519) . Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity) .