FXN antibody
Product Specifications
Background
FXN, also named as FRDA, X25, m81-FXN, d-FXN, m78-FXN and i-FXN, belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. The mature form of FXN is 14 or 18kDa.
Synonyms
Frataxin, mitochondrial|Friedreich ataxia protein (Fxn) |Frataxin intermediate form (i-FXN) |Frataxin (56-210) Alternative names: m56-FXN|Frataxin (78-210) Alternative names: d-FXN|m78-FXN|Frataxin mature form Alternative names: Frataxin (81-210) |m81-FXN|Extramitochondrial frataxin|FXN|FRDA|X25
Gene ID
2395
UniProt
Q16595
Host
Rabbit
Reactivity
Human
Immunogen
Frataxin
Target
FXN
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cancer, Neuroscience, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
14 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Curated Selection
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