FRK antibody
Product Specifications
Background
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Synonyms
Tyrosine-protein kinase FRK|FYN-related kinase|Nuclear tyrosine protein kinase RAK|Protein-tyrosine kinase 5|FRK|PTK5|RAK
Gene ID
2444
UniProt
P42685
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fyn-related kinase
Target
FRK
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Signal Transduction, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54-57 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
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