FOLR1 antibody
Product Specifications
Background
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Synonyms
Folate receptor alpha (FR-alpha) |Adult folate-binding protein (FBP) |Folate receptor 1|Folate receptor, adult|KB cells FBP|Ovarian tumor-associated antigen MOv18|FOLR1|FOLR
Gene ID
2348
UniProt
P15328
Host
Rabbit
Reactivity
Human
Immunogen
Folate receptor 1
Target
FOLR1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF,IHC
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
38 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC
Immunogen Sequence
25-93aa
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