FMN2 antibody
Product Specifications
Background
Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis(By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.
Synonyms
Formin-2|FMN2
Gene ID
56776
UniProt
Q9NZ56
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
formin 2
Target
FMN2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Neuroscience, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
195 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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