FBP1 antibody
Product Specifications
Background
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Synonyms
Fructose-1,6-bisphosphatase 1 (FBPase 1) |D-fructose-1,6-bisphosphate 1-phosphohydrolase 1|Liver FBPase|FBP1|FBP
Gene ID
2203
UniProt
P09467
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fructose-1,6-bisphosphatase 1
Target
FBP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:5000-1:20000; IP: 1:500-1:1000; IHC: 1:100-1:400; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
37 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF, IP
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