FBL antibody
Product Specifications
Background
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Synonyms
rRNA 2'-O-methyltransferase fibrillarin|34 kDa nucleolar scleroderma antigen|Histone-glutamine methyltransferase|U6 snRNA 2'-O-methyltransferase fibrillarin|FBL|FIB1|FLRN
Gene ID
2091
UniProt
P22087
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
fibrillarin
Target
FBL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, IHC, WB, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200; IP: 1:20 - 1:50
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
37 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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