EYA1 antibody

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity) . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442) . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity) . Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity) . Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity) . Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity) .