PDIA3 antibody
Product Specifications
Background
PDIA3, also named as P58, ER60, ERp57, ERp60, ERp61, GRP57, GRP58 and PI-PLC, is a member of the PDI family, participates in the oxidation, reduction, and isomerization of disulfide bonds for correct folding of secretory proteins before modification and transport in the endoplasmic reticulum. It is associated with apoptosis or inhibition of cancer cell growth. PDIA3 was once thought to be a phospholipase; however, it has been demonstrated that this protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and PDIA3 mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
Synonyms
Protein disulfide-isomerase A3|58 kDa glucose-regulated protein|58 kDa microsomal protein (p58) |Disulfide isomerase ER-60|Endoplasmic reticulum resident protein 57 (ER protein 57, ERp57) |Endoplasmic reticulum resident protein 60 (ER protein 60, ERp60) |PDIA3|ERP57|ERP60|GRP58
UniProt
P30101
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein disulfide isomerase family A, member 3
Target
PDIA3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, FC, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2400; IP: 1:1000-1:4000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, FC, IP
Curated Selection
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