ERCC2 antibody
Product Specifications
Background
ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair(NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase(CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Synonyms
General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD)|Basic transcription factor 2 80 kDa subunit (BTF2 p80)|CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH basal transcription factor complex 80 kDa subunit (TFIIH 80 kDa subunit, TFIIH p80)|Xeroderma pigmentosum group D-complementing protein|ERCC2|XPD|XPDC
Gene ID
2068
UniProt
P18074
Host
Rabbit
Reactivity
Human
Immunogen
excision repair cross-complementing rodent repair deficiency, complementation group 2
Target
ERCC2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Epigenetics, Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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