ERBB4 antibody
Product Specifications
Background
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Synonyms
Receptor tyrosine-protein kinase erbB-4|Proto-oncogene-like protein c-ErbB-4|Tyrosine kinase-type cell surface receptor HER4|p180erbB4|ERBB4 intracellular domain (4ICD, E4ICD) Alternative names: s80HER4|ERBB4|HER4
Gene ID
2066
UniProt
Q15303
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Target
ERBB4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
180 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
