EIF3D antibody
Product Specifications
Background
Component of the eukaryotic translation initiation factor 3(eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex(43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2(PubMed:18056426).
Synonyms
Eukaryotic translation initiation factor 3 subunit D (eIF3d)|Eukaryotic translation initiation factor 3 subunit 7|eIF-3-zeta|eIF3 p66|EIF3D|EIF3S7
Gene ID
8664
UniProt
O15371
Host
Rabbit
Reactivity
Human, Mouse, Yeast
Immunogen
eukaryotic translation initiation factor 3, subunit D
Target
EIF3D
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, IHC, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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