EDEM2 antibody
Product Specifications
Background
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655) . Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Synonyms
ER degradation-enhancing alpha-mannosidase-like protein 2|EDEM2|C20orf31|C20orf49
Gene ID
55741
UniProt
Q9BV94
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ER degradation enhancer, mannosidase alpha-like 2
Target
EDEM2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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